The rapid progress of genomic technologies has been providing new opportunities to address the need of maturity-onset diabetes of the young (MODY) molecular diagnosis.However, whether a new mutation causes MODY can be questionable.A number of in silico methods have been developed to predict functional effects of rare human mutations.The purpose of
Abstract The cytoskeletal protein actin plays a critical role in the pathogenicity of the intracellular parasite, Toxoplasma gondii, mediating invasion and egress, cargo transport, and organelle inheritance.Advances in live Handheld Vacuum Wheel cell imaging have revealed extensive filamentous actin networks in the Apicomplexan parasite, but there
Abstract Background Neurons assemble into a functional network through a sequence of developmental processes including neuronal polarization and synapse formation.In Caenorhabditis elegans, the serine/threonine SAD-1 kinase is essential for proper neuronal polarity and synaptic organization.To determine if SAD-1 activity regulates the establishment
Splenosis is a rare condition described as the Holdalls implantation of ectopic splenic tissue, usually after a splenic rupture.Thoracic splenosis refers to acquired ectopic splenic tissue found within the thoracic cavity, often caused by thoracoabdominal trauma or surgery.Most cases are asymptomatic and many years may elapse before they are incide
This paper provides an empirical assessment of the relationship between common European Union and country-specific risk factors of sovereign bond spreads for Central and Eastern European countries over the period of 2004-2014.The model, estimated using Pooled Mean Group techniques, that accounts for both common long-run determinants and cross-count